Efficacy of posaconazole in a murine model of central nervous system aspergillosis.
نویسندگان
چکیده
Human central nervous system (CNS) aspergillosis has >90% mortality. We compared posaconazole with other antifungals for efficacy against murine CNS aspergillosis. All tested regimens of posaconazole were equivalent to those of amphotericin B and superior in prolonging survival and reducing CFU to those of itraconazole and caspofungin and to vehicle controls. No antifungal regimen effected cure. No toxicity was noted. Overall, posaconazole shows potential for treating CNS aspergillosis.
منابع مشابه
Review of the Aspergillosis and Report A Case of its Central Nervous System
SUMMARY Because Aspergillus SP. are one of the most common airborne fungal contaminants in all parts of the world, the incidence of Aspergillosis is relatively high, but will not be diagnosed in some cases. In this survey we decided to review the importance of Aspergillosis and also to report a case of its Central Nervous system involvement in a patient without Immunodeficiency.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 48 10 شماره
صفحات -
تاریخ انتشار 2004